There are many shortcomings to this system, which can lead to considerable frustration. A heat sink is applied to the top of the tissue at the proper moment to speed the freezing process and flatten the surface of the tissue to create a flat plane. The tissue holder or "chuck" is then set upon a freezing temperature bar. In conventional cryostats, tissue is embedded for frozen section by placing it face up on a tissue holder and covered with an embedding medium. Although embedding some cases is a simple process where orientation is not critical, there are many specimens where our ability to provide an answer relies on perfect orientation of the specimen within the block. This article will concern itself with the process of embedding tissue for frozen section. At each of these steps, a poor preparation can yield disastrous results. These include gross examination and sampling of the tissue, accurate embedding of the tissue, cutting and staining high-quality slides, and finally interpreting the slide(s). To provide the necessary answers to the questions put before us in the frozen section room, there are a number of steps that must be performed without flaw. This sense of wariness remains with a pathologist throughout his or her career. This formidable task is a sharp taste of reality. The pathologist, armed only with a few jars of stain and a cryostat, is asked to steer the course of a patient's surgery based on a small sample of tissue. They can also move a new piece out even if they have another piece currently in play, and can also do the same if another player's piece is occupying their "start" space, but cannot do so when one of their own pieces is occupying their "start" space.As a practicing pathologist, I can think of no more intimidating task than preparing and interpreting the frozen section. Getting a 6 at any point in the game also allows the player to take another turn, even if the player cannot move any of their pieces (as they cannot land on any of their own pieces). Players may move pieces out of their start only when the die lands on 6. The die is imprinted with Arabic numerals rather than the traditional circular pips (though the circular pips are used in the Travel version, which contains a cover to keep the pegs from being lost). It allows for quick die rolls, and players' turns can be performed in rapid succession. The Pop-O-Matic container produces a popping sound when it is used, and prevents the die from being lost (and players from cheating by improper rolling). Players roll the die by pressing down quickly on the bubble, which flexes the sheet and causes the die to tumble upon its rebound. This device is a clear plastic hemisphere containing the die, placed over a flexible sheet. The most notable feature of Trouble is the "Pop-O-Matic" die container. Unlike more complex race games such as Parcheesi, counters cannot be maneuvered to block opponents' moves. Pieces are protected from capture after arriving in the final four slots. Players can send opponents' pieces back to the start by landing on them. Ī similar game called Headache was also produced by the Milton Bradley Company besides a different track layout, its pawns are conical, in contrast to the cylindrical pieces used in Trouble. The gameplay, board, and concept is derivative of the British board game Ludo, itself based on the Indian board game pachisi. The classic version is now marketed by Winning Moves Games USA. The game was launched in America in 1965. Trouble was developed by the Kohner Brothers and initially manufactured by Irwin Toy Ltd., later by Milton Bradley (now part of Hasbro). Pieces are moved according to the roll of a die using a contained device called a "Pop-O-Matic". Trouble (known as Frustration in the UK and Kimble in Finland) is a board game in which players compete to be the first to send four pieces all the way around a board.
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